Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutchs pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer with minimal side effects. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nations first and largest cancer prevention research program, as well as the clinical coordinating center of the Womens Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
As a Research Tech Level II, the position acts both independently and as a team collaborator within the lab to lead multiple laboratory projects including but not limited to isolation, enrichment, transduction and expansion of T cells/Stem Cells, complex analytical procedures, data compilation/interpretation, and generating detailed technical reports/presentations. In addition, this position helps identify emerging technologies and automation, monitors industry trends and conducts evaluations for feasibility. This position works with and under the guidance of a lab supervisor for experimental design, study execution, data analysis and data interpretation. The candidate also interacts heavily with internal and external research and principal investigator labs, GMP manufacturing, Quality Control, Quality Assurance, and other scientific/administrative staff, as needed.
The position focuses on the development, optimization, and transfer of cellular and gene therapy unit operations including cell selections from starting materials, genetic modifications (viral transduction, electroporation, etc.), growth/expansion conditions, media/cytokine formulations, cell harvests, cryopreservation, and freeze-thaw recovery. In addition, this position collaborates to develop robust and repeatable analytical methods to characterize starting, in-process and final, formulated cellular products. Ultimately, development activities generate robust, repeatable and scalable processes to support toxicology studies, technology transfer/product introduction into the Fred Hutch GMP Cell Processing manufacturing facility, and IND generation to enable clinical trial initiation.
Research Tech II: BS/MS in a biological sciences discipline, and 2+ years' (BS) or 1+ years' (MS) experience in mammalian cell culture
Research Tech III: BS/MS in a biological sciences discipline, and 5+ years' experience in mammalian cell culture or Process Development
Experience in one or more of the following technical areas:
Associated upstream and downstream unit operations such as cell banking, virus removal, purification, etc.
Cryopreservation and recovery of cryopreserved cells.
Experience with gene editing platforms (i.e. Crispr/cas9 system)
Demonstrated experience trouble-shooting issues associated with process scale-up, transfer into a GMP manufacturing setting, and generating process transfer documentation.
Direct experience in a Process Development environment supporting aseptic cell culture-based manufacturing operations
1+ years hands-on experience with flow cytometry and T-cell/stem cell isolation/expansion protocols
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At Fred Hutchinson Cancer Research Center, teams of world-renowned scientists and humanitarians work together to prevent, diagnose and treat cancer, HIV/AIDS and other diseases. Researchers are discovering new ways to detect cancers earlier, improve treatments, and learn how to prevent cancers from growing. Although Fred Hutchinson opened its doors in 1975, its history began about 20 years before that. In 1962 Fred Hutchinson envisioned a center devoted to studying cancer, a disease that took his brother’s life. Today Fred Hutchinson is contributing to the next waves of breakthrough treatments and prevention strategies. Fred Hutchinson collaborates with the Seattle Cancer Alliance, the National Cancer Institute, and the University of Washington.