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The Uganda Cancer Institute/Hutchinson Center Cancer Alliance (UCI/HCCA) is a collaborative undertaking that has established a state-of-the-art cancer treatment and research facility located in Kampala, Uganda. The activities carried out by the Hutchinson Center in Uganda in support of this alliance are performed under the auspices of the Hutchinson Centre Research Institute of Uganda (HCRI-Uganda or HCRI-Ug). A primary objective of the collaboration between the Global Oncology Program at the Hutchinson Center and the Uganda Cancer Institute is the development of innovative, low-cost cancer prevention and treatment strategies that are appropriate for low- and middle-income countries (LMICs). The UCI/HCCA also has a strong focus on ameliorating the high burden of infection-related cancers in LMICs. Clinicians and scientists at the UCI/HCCA work together to enhance patient access to care, diagnosis, and research-based treatment. In addition to the UCI/HCCA, the Hutchinson Centers Global Oncology Program supports research activities in several other countries, which collectively carry out the mission of the Program to conduct high-quality research and capacity-building on an international scale.
This individual will serve as a Biorepository Technician for the Global Oncology Programs laboratory operations which operates at the UCI Fred Hutch Cancer Centre (UCI FHCC), a 25,000-square foot cancer research and treatment building on Mulago Hill in Kampala that opened in May 2015. The laboratory facilities of the UCI FHCC are primarily located on the third floor of the building and include a Specimen Processing Lab, Molecular Diagnostics Lab, Histopathology Lab and BSL2+ Lab. There is also dedicated space on the third floor for a future Immunology Lab.
The Employee will serve and train under the immediate supervision of the Laboratory Director and will be based in Seattle full-time. The incumbent will report to the Laboratory Director. The incumbents primary responsibility will be to manage and ensure the proper functioning of all daily activities within the Global Oncologys biorepository on the Seattle side and work cohesively with the Laboratory Data Coordinator in Kampala for the HCRI-Ug. Additionally, they are expected to organize, receive and QC/QA all shipments for samples and reagents going between the two sites under the supervision of the Laboratory Director. The Biorepository Technician will act as a liaison between the Laboratory Director and the study teams, the Fred Hutch research cell bank and Freezer Farm along with collaborators in regard to responsibility for all samples that are accrued and banked with the Global Oncology Program. The position will require the individual to be knowledgeable in all laboratory activities as well as other project activities that pertain to the laboratory and its scientific development and GCLP and biobanking. The individual may be required to assist the Laboratory Director in teaching new technicians, visiting scientists and students in laboratory practices pertaining to the repository.
In addition to the Global Oncology Program, the Biorepository Technician will spend at least 40 percent of their time with the Warren Laboratory in the Immunology Department which is a part of the Clinical Research Division. This role will be similar to assisting with the Warren Laboratorys biorepository, shipping and receiving and act as a liaison between the Warren Laboratory and the UW study teams, the Fred Hutch research cell bank and Freezer Farm along with collaborators in regard to responsibility for all samples that are accrued and banked with the laboratorys ongoing studies.
Applicants demonstrates and promotes Good Clinical Laboratory Principles (GCLP) in all areas of responsibility.
Operate independently to resolve issues as they arise, utilize good judgment to determine if additional resources, staff or supervisor needs to be notified or included in decision making.
Communicate with multiple internal and external working groups, investigators and organizations to ensure repository shipping requirements and obligations are met with high customer service standards.
Perform specimen processing laboratory back up activities including; the isolation and cryopreservation of Peripheral Blood Mononuclear Cells (PBMC) from whole blood or leukapheresis, serum, plasma and semen isolation and freezing and understanding of HIV clinical trials protocol logistics and specimen requirements.
Help support in conjunction with the Laboratory Director to oversee and train new lab staff and students in repository safety, operations, procedures and handling of hazardous materials.
Demonstrate working knowledge with Laboratory Information Management Systems (LIMS) and Microsoft Access, including queries, form building and reporting.
Develop/update, create and maintain SOPs and other guidance and reference materials relevant to specimen handling /shipping and their logging into the inventory database related to their respective repositories.
Function as primary repository floor liaison and responder with Fred Hutch facility engineers and external vendors on repository projects including planning, logistics, technical equipment inquiries, alarms, supplies and other various tasks related to the startup operations and maintenance of expanded repository space and functions.
Function as liaison with LIMS programmers to develop and define user requirements, functionality, work flow, inquiries, data migration, data transfer and reporting features for new Labware LIMS systems. Report on progress, anticipated or existing problems, and discuss the work to be performed with the repository manager, lab manager and LIMS programmers.
Perform and document quality control procedures and maintain accurate records for cleaning, maintenance and monitoring activities for temperature sensitive equipment, specimen management, shipping and receiving for domestic and International biological research specimens and reagents according to IATA requirements.
Draft and review SOPs, SSPs, Lab Manuals and Study Plans where needed pertaining to biobanking and the biorepository primarily in Seattle.
Familiarize with the GO Laboratory SharePoint Site and the HCRI-Uganda Laboratory Server
Establish and maintain a good relationship with the other laboratory sections in the UCI-FHCC (pharmacy and STAT clinic lab) and support those sections in biorepository and sample maintenance, training and documentation.
Oversee the coordination of other vendor/collaborator contract/agreements and renewals (g., standing orders, annual quotes from major suppliers, etc.) for reagents, consumables, PPE, and other laboratory supplies. Manage the HCRI-Uganda Ordering List.
Help support when needed all laboratory supply and ordering needs in coordination with the Procurement Officer, Laboratory Director and Laboratory Technicians to ensure that at all times supplies are available for use in the Laboratory for the UCI-FHCC team.
Familiarize with the FH Financial Management System for ordering of supplies, equipment and services.
Together with the Laboratory Director oversee initial and annual competency and proficiency of employees on each research and clinical assay.
Assist the Laboratory Director in the set-up of GCLP compliance with the goal of future accreditation or maintaining accreditation, as appropriate, in UCI FHCC component laboratories.
Prepare for and participate in internal/external audits of the laboratory.
Oversee maintenance and training on the specimen tracking system Freezerworks.
Oversee and perform quarterly audits of GO and WarrenLaboratory biorepository specimen storage to assess accuracy and completeness.
Oversee pulling of specimen for shipment. Review Shipping paperwork if needed. Supervise local and international shipment of samples. Establish a relationship with local and international shipping courier services.
Work closely with the HCRI-Ug Procurement Officer and administration for obtaining URA tax exemptions and National Drug Authority verification letters for shipment. Familiarize with the NDA Portal. Work closely with HCRIU regulatory office for further permits if needed.
Ensure that the laboratory maintains a clean and safe working environment. The Laboratory Manager should coordinate these activities with the HCRI-Ug Laboratory Safety Officer and EH&S Officer.
Work Occasional off-hours (evenings and weekends) in response to out-of-range freezer alarms or equipment malfunction.
Must have a positive attitude and patience and a good work ethic.
Other duties as assigned.
A bachelors degree in the biological sciences and laboratory bench research experience are required. Experience with cell culture techniques, and blood processing is preferred. The technician must show initiative, the willingness to take up new skills and responsibilities, and be a team player. Excellent attention to detail and the ability to work independently are essential to success in this position, as are good communication and organizational skills.Salary will be commensurate with (appropriate) experience.
IATA biological diagnostics, dangerous goods and infectious substances shipping preferred.
Bachelors degree with 3+ years of experience.
Extensive knowledge and proficiency in working in a GCLP and clinical trial environment.
Previous experience in an accredited laboratory is preferred.
Proficiency in a variety of laboratory assays and techniques and lab operation.
Experience with oncology or Infectious disease preferred.
The successful candidate must be able to work accurately and efficiently, be detail oriented, and work both independently and within a group.
Strong troubleshooting and problem-solving skills are required.
This position requires excellent written and verbal communication skills and the ability to work positively in a group environment.
A high degree of professionalism and management ability is required of this position as well as interpersonal abilities to motivate individuals to perform in an efficient and productive manner
The candidate in this position must be flexible and skilled at organizing and prioritizing tasks. Familiarity with Microsoft Word, Excel, and Internet Explorer is desirable.
Familiarity with a laboratory information management system (LIMS) such as Freezerworks is a plus.
Biobank training or IATA dangerous goods certification training is preferred
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At Fred Hutchinson Cancer Research Center, teams of world-renowned scientists and humanitarians work together to prevent, diagnose and treat cancer, HIV/AIDS and other diseases. Researchers are discovering new ways to detect cancers earlier, improve treatments, and learn how to prevent cancers from growing. Although Fred Hutchinson opened its doors in 1975, its history began about 20 years before that. In 1962 Fred Hutchinson envisioned a center devoted to studying cancer, a disease that took his brother’s life. Today Fred Hutchinson is contributing to the next waves of breakthrough treatments and prevention strategies. Fred Hutchinson collaborates with the Seattle Cancer Alliance, the National Cancer Institute, and the University of Washington.